Total Synthesis of (±)-Mycoepoxydiene, a Novel Fungal Metabolite Having an Oxygen-Bridged Cyclooctadiene Skeleton

Total synthesis of optically active coty

Total synthesis of optically active cotylenol, a fungal metabolite having a leaf growth activity. Intramolecular ene reaction for an eight-membered ring formation

✍ Nobuo Kato; Hiroaki Okamoto; Hitoshi Takeshita 📂 Article 📅 1996 🏛 Elsevier Science 🌐 French ⚖ 880 KB

Starting from condensation of two iridoid synthons, (3S,8R)-benzyloxy-l-iriden-7-al and (3R)-7-chloro-l-iridene, cotylenol, one of the representative fusicoccane diterpenoids having 5-8-5-membered tricyclic carbon framework, is now synthesized for the first time via an eight-membered ring formation