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Total synthesis of (–)-MY 336a from L-tyrosine

✍ Scribed by Xiang Wei Liao; Wen Fang Dong; Wei Liu; Bao He Guan; Zhan Zhu Liu

Publisher: Journal of Heterocyclic Chemistry
Year: 2009
Tongue: English
Weight: 73 KB
Volume: 47
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.248

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✦ Synopsis

Abstract

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Using L‐tyrosine as a chiral starting material, we developed an efficient synthetic route to (–)‐MY 336a. A key step in the sequence is a highly regio‐ and diastereoselective intermolecular Pictet‐Spengler cyclization reaction between amino alcohol and benzyloxyacetaldehyde. J. Heterocyclic Chem., (2010).

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