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Total synthesis of marinostatin, a serine protease inhibitor isolated from the marine bacterium Pseudoallteromonas sagamiensis

✍ Scribed by Misako Taichi; Toshimasa Yamazaki; Terutoshi Kimura; Yuji Nishiuchi

Book ID: 108285460
Publisher: Elsevier Science
Year: 2009
Tongue: French
Weight: 287 KB
Volume: 50
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2009.02.213

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## Abstract A 12‐residue MST isolated from a marine organism is a potent serine protease inhibitor that has a double cyclic structure composed of two ester linkages formed between the β‐hydroxyl and β‐carboxyl groups, Thr^3^‐Asp^9^ and Ser^8^‐Asp^11^. MST was synthesized by a regioselective esterif