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Total synthesis of marine alkaloids (±)-hapalindoles J and M

✍ Scribed by Hideaki Muratake; Mitsutaka Natsume

Publisher
Elsevier Science
Year
1989
Tongue
French
Weight
319 KB
Volume
30
Category
Article
ISSN
0040-4039

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✦ Synopsis

Marine alkaloids hapalindoles J 1 and M 2 were concisely synthesized in the racemic form from a tertiary alcohol 4 by way of 7, 9, 11, and 17, using unusual LiAlH4 reduction of fl as a key reaction step. Hapalindoles and related indole derivatives are antibacterial and antimycotic alkaloids obtained from the blue-green alga HapaZosiphon fantinaZis by Moore and co-laborators. 1,2,3 Recently indolinones, having similar structures,

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