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Total Synthesis of Laulimalide: Synthesis of the Northern and Southern Fragments

✍ Scribed by Prof. Barry M. Trost; Dr. W. Michael Seganish; Dr. Cheol K. Chung; Dr. Dominique Amans


Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
456 KB
Volume
18
Category
Article
ISSN
0947-6539

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πŸ“œ SIMILAR VOLUMES


Total Synthesis of Laulimalide: Assembly
✍ Prof. Barry M. Trost; Dr. Dominique Amans; Dr. W. Michael Seganish; Dr. Cheol K. πŸ“‚ Article πŸ“… 2012 πŸ› John Wiley and Sons 🌐 English βš– 481 KB πŸ‘ 1 views

## Abstract Herein, we present a full account of our efforts to couple the northern and the southern building blocks, the synthesis of which were described in the preceding paper, along with the modifications required to ultimately lead to a successful synthesis of laulimalide. Key highlights inclu

The Laulimalide Family: Total Synthesis
✍ Andreas Gollner; Karl-Heinz Altmann; JΓΌrg Gertsch; Johann Mulzer πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 516 KB

## Abstract **A sensitive family**: The first total synthesis of the antitumor agents neolaulimalide and isolaulimalide as well as a highly efficient route to laulimalide is described. A Kulinkovich reaction followed by a cyclopropyl–allyl rearrangement is used to install the __exo__‐methylene grou