Total Synthesis of Laulimalide: Synthesis of the Northern and Southern Fragments
β Scribed by Prof. Barry M. Trost; Dr. W. Michael Seganish; Dr. Cheol K. Chung; Dr. Dominique Amans
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 456 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0947-6539
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π SIMILAR VOLUMES
## Abstract Herein, we present a full account of our efforts to couple the northern and the southern building blocks, the synthesis of which were described in the preceding paper, along with the modifications required to ultimately lead to a successful synthesis of laulimalide. Key highlights inclu
## Abstract **A sensitive family**: The first total synthesis of the antitumor agents neolaulimalide and isolaulimalide as well as a highly efficient route to laulimalide is described. A Kulinkovich reaction followed by a cyclopropylβallyl rearrangement is used to install the __exo__βmethylene grou