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Total Synthesis of (+)-Lactacystin from (R)-Glutamate

✍ Scribed by Uno, Hidemitsu; Baldwin, Jack E.; Russell, Andrew T.


Book ID
120587628
Publisher
American Chemical Society
Year
1994
Tongue
English
Weight
186 KB
Volume
116
Category
Article
ISSN
0002-7863

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The chiral and stereoselective synthesis of (+)-lactacystin 1, the first non-protein neurotrophic factor having an ct,~t-disubstituted a-amino acid structure, is described. The highly functionalized y-lactam portion possessing a tetra-substituted carbon with nitrogen in I was effectively constructed