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Total synthesis of isoprostanes via the two-component coupling process

✍ Scribed by Ana R. Rodrı́guez; Bernd W. Spur

Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
127 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis

A short total synthesis of isoprostanes has been achieved using a two-component coupling process combined with a diastereoselective protonation under reagent control. The F 1 -isoprostanes were easily obtained by stereoselective reduction of the C-9 keto group.

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