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Total synthesis of (±)-iso-d4T as potential antiviral agent

✍ Scribed by Lak Shin Jeong; Young A Lee; Hyung Ryong Moon; Su Jeong Yoo; Su Youn Kim

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
183 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

+)-Iso-d4T which may act as a bioisostere of d4T was synthesized from 1,3-dihydroxyacetone using phenyl selenenium chemistry as a key step.

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✍ Qi Chao; Vasu Nair 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 707 KB

Two novel classes of bicarbocyclic dideoxynucleosides have been synthesized for antiviral studies. The key intermediates, 9 and 23, synthesized in multiple steps from readily available monocyclic or bicyclic precursors, were coupled with the desired heterocyclic bases to afford, after further elabor