Total Synthesis of Halipeptins A and D and Analogues
β Scribed by K. C. Nicolaou; David W. Kim; Daniel Schlawe; Dimitrios E. Lizos; Rita G. de Noronha; Deborah A. Longbottom
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 155 KB
- Volume
- 117
- Category
- Article
- ISSN
- 0044-8249
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π SIMILAR VOLUMES
The halipeptins A (1) and B (2) are two cyclic depsipeptides that were isolated from the sponge Haliclona species by Gomez-Paloma and co-workers. [1,2] Initially, their structures were misassigned as the 17-membered cyclic depsipeptides containing an unusual oxazetidine. [1] One year later the same
## Abstract The total synthesis of apoptolidin A is described employing an early glycosylation strategy. Strategic disconnections were chosen between C11βC12 (crossβcoupling) and C19OβC1 (macrocyclization). The __cis__βselective glycosylation at C9βOH was achieved with the new SIBA protective group