Total Synthesis of (+)-Grandifloracin by Iron Complexation of a Microbial Arene Oxidation Product
✍ Scribed by Palframan, Matthew J.; Kociok-Köhn, Gabriele; Lewis, Simon E.
- Book ID
- 125837785
- Publisher
- American Chemical Society
- Year
- 2011
- Tongue
- English
- Weight
- 799 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1523-7060
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📜 SIMILAR VOLUMES
The octahydronaphthopyranone moiety is synthesized from methyl ~t-D-mannopyranoside through the intramolecular Diels-Alder reaction, and the tetmenedicarboxylic acid moiety is from the enzymatically prepared anti-compound. Both moieties were coupled to accomplish the total synthesis of calbistrin A
2,6-Cyclolycopene-l,5-diol (3) was synthesized in 9 steps starting from ¢t-terpinyl acetate (11). This represents the first total synthesis of an oxidative metabolite of lycopene (2). The synthesis was performed according to a C~.s + C~o + Cm5 = C40 strategy using the Wittig olefination to couple th