Total synthesis of forskolin — Part III studies related to an asymmetric synthesis
✍ Scribed by Daniel Calvo; Marc Port; Bernard Delpech; Robert Lett
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 132 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
## Abstract A six‐step asymmetric total synthesis of (20__S__)‐camptothecin (**1**) has been accomplished in 25% overall yield starting from the known pyridone **3**. The key steps in this synthesis are the chemoselective Ni‐catalyzed hydrogenation of 3‐cyanopyridone **6** to 3‐formylpyridone **7**
Study Toward the Total Synthesis of Forskolin. Part 2. Synthesis of the Epoxy-triene as the Key Intermediates. -Compound (VII) is a key intermediate for the synthesis of forskolin which shows promising potential as a novel drug for the treatment of diseases such as glancoma, congestive heart failur