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Total synthesis of erythromycins. 3. Stereoselective routes to intermediates corresponding to C(1) to C(9) and C(10) to C(13) fragments of erythronolide B

โœ Scribed by Corey, E. J.; Trybulski, Eugene J.; Melvin, Lawrence S.; Nicolaou, K. C.; Secrist, John A.; Lett, Robert; Sheldrake, Peter W.; Falck, J. R.; Brunelle, Daniel J.


Book ID
121356810
Publisher
American Chemical Society
Year
1978
Tongue
English
Weight
412 KB
Volume
100
Category
Article
ISSN
0002-7863

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A stereoselective osmylation approach to
โœ Gyu Kim Young; Whang Konghyun; R.J. Cooke; Jin K. Cha ๐Ÿ“‚ Article ๐Ÿ“… 1990 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 284 KB

The key synthons 2 and 3 [with suitable protecting groups] of the erythronolide A seco acid (1) have been prepared in an enantiomerically pure form, utilizing a stereoselective osmylation of chiral hydroxy (Z,E)-diene ester 6a and subsequent hydrogenation. Recent interest in macrolide and ionophore