Total Synthesis of Epothilone E and Analogues with Modified Side Chains through the Stille Coupling Reaction
β Scribed by K. C. Nicolaou; Yun He; Frank Roschangar; N. Paul King; Dionisios Vourloumis; Tianhu Li
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 129 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0044-8249
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Trikoningin KB II, a ten-amino acid residue lipopeptaibol blocked at the N-terminus by the n-octanoyl group and at the C-terminus by the 1,2-amino alcohol L-leucinol, and extracted from the fungus Trichoderma koningii, exhibits membrane-modifying properties. We have synthesized by solution-phase met