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Total synthesis of d,l-purpurosamine c

✍ Scribed by Adam Gołebiowski; Ulla Jacobsson; Marek Chmielewski; Janusz Jurczak


Book ID
108372349
Publisher
Elsevier Science
Year
1987
Tongue
French
Weight
448 KB
Volume
43
Category
Article
ISSN
0040-4020

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High pressure approach to the total synt
✍ Adam Gołȩbiowski; Janusz Jurczak; Ulla Jacobsson 📂 Article 📅 1987 🏛 Elsevier Science 🌐 French ⚖ 310 KB

Methyl 2,6-di-I-acetyl-6-epia-&-purpurosaminide B (11) was synthesized from L-alanine by an eleven-step reaction sequence. Eu(fod)a-mediated high-pressure (4t2)cycloaddition of 1-methoxybuta-1,3-diene (2) to a-amino aldehyde 3, easily available from Galanine (A), is the key step in the synthetic seq