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Total synthesis of d,1-megaphone

✍ Scribed by P.A. Zoretic; C. Bhakta; R.H. Khan

Publisher: Elsevier Science
Year: 1983
Tongue: French
Weight: 214 KB
Volume: 24
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)86382-0

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✦ Synopsis

The Synthesis of racemic megaphone 1, a cytotoxic neolignan, is described. Three new cytotoxic neolignans, megaphone 1, megaphone acetate 2 and megaphyllone ace-tate 3 have recently been isolated from Aniba megaphylla Mex. _ (Laureaceae)' by Kupchan and co-workers. These new neolignans were found to demonstrate "inhibitor activity, in vitro, against cells derived thesis of megaphone 1 _ describe an alternate '^ 15, as a key synthon, RO from human carcinoma of the nasopharynx (KB)."' Recently a total synand its acetate 2 has been reported by B&hi and Chu.

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