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Total synthesis of (+)-crocacin D

✍ Scribed by Tushar K Chakraborty; Pasunoori Laxman

Book ID
104250713
Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
107 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis

The first total synthesis of the potent antifungal and cytotoxic agent (+)-crocacin D in optically pure form following a convergent strategy is described here. The regioselective ring opening of a silyl-substituted epoxide with an azide ion, based on a method developed by us earlier, and subsequent subjection of the resulting a-azido-b-hydroxyalkylsilane intermediate to a Peterson elimination reaction at an appropriate stage during the synthesis constituted the key steps for the stereoselective construction of the crucial cis enamide moiety of the molecule.

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Total Synthesis of (+)-Crocacin D †
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ChemInform Abstract: Total Synthesis of
ChemInform Abstract: Total Synthesis of (+)-Crocacin D.
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