✦ LIBER ✦
Total synthesis of coronafacic acid through 6-endo-trig mode intramolecular cyclization of an enone-aldehyde to a hydrindanone using samarium(II) iodide
✍ Scribed by Masakazu Sono; Atsuko Hashimoto; Katsuyuki Nakashima; Motoo Tori
- Book ID
- 104210479
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- French
- Weight
- 124 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
Coronafacic acid has been synthesized from a hydrindanone prepared by a 6-endo-trig mode cyclization reaction of the enone-aldehyde with samarium(II) iodide. The stereochemistry of the hydrindanone was controlled by the coordinated samarium species resulting in cis in respect of the hydroxyl group at C-4 and the juncture proton at C-3a.