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Total Synthesis of (+)-Concanamycin F

✍ Scribed by Ian Paterson; Victoria A. Doughty; Malcolm D. McLeod; Thomas Trieselmann


Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
146 KB
Volume
39
Category
Article
ISSN
0044-8249

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The concanamycin group of macrolides, first isolated from a culture of Streptomyces diastatochromogenes Sp. S45 by Kinashi and co-workers and typified by concanamycin A (1, Figure 1) [1aΒ±d] and its aglycone, concanamycin F 2), [1e,f] exhibit potent inhibition of vacuolar (H ) ATPase activity. [2] Th

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