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Total synthesis of cis-6-methoxy-1,1-dimethylcarbapen-2-em

✍ Scribed by Daniel T.W Chu; John E Hengeveld; David Lester

Book ID
104216876
Publisher
Elsevier Science
Year
1983
Tongue
French
Weight
217 KB
Volume
24
Category
Article
ISSN
0040-4039

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✦ Synopsis

The total synthesis of the title compound via an intramolecular aldol condensation, and the novel use of the trimethylsilylethyl ester as a carboxyl protecting group in carbapenem systems, are reported.

πŸ“œ SIMILAR VOLUMES

Synthesis of 1-methoxy canthine-6-one
Synthesis of 1-methoxy canthine-6-one
✍ Timothy J. Hagen; James M. Cook πŸ“‚ Article πŸ“… 1988 πŸ› Elsevier Science 🌐 French βš– 221 KB

The six step synthesis of the cytotoxic antileukemic alkaloid 1-methoxy canthine-&one 2 is described. The pivotal steps m represented by the oxidation (DDQ) of 9 to tiord the 3-acylindole 14 and the conversion of 11 into the 4-methoxy-1-alkyl fl-carboline 15. A number of canthine-6-one alkaloids h