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Total Synthesis of (±)-Cerulenin and (±)-Tetrahydrocerulenin

✍ Scribed by Nozoe, Shigeo; Ohta, Tomihisa; Tsuchiyama, Hiroyuki


Book ID
115520981
Publisher
Japan Institute of Heterocyclic Chemistry
Year
1986
Tongue
English
Weight
173 KB
Volume
24
Category
Article
ISSN
0385-5414

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📜 SIMILAR VOLUMES


A total synthesis of (±)cerulenin
✍ E.J. Corey; David R. Williams 📂 Article 📅 1977 🏛 Elsevier Science 🌐 French ⚖ 230 KB

The antifungal antibiotic, cerulenin 3 was isolated from the culture filtrate of Cephalosporium caerulens, 1 and shown to inhibit lipid biosynthesis of Escherichia coli by irreversibly binding P-ketoacyl-acyl carrier protein synthetase, the enzyme which catalyzes the acylation of a malonyl thioester