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Total synthesis of ceramide trihexoside accumulating with fabry's disease

✍ Scribed by David Shapiro; A.J. Acher

Publisher: Elsevier Science
Year: 1978
Tongue: English
Weight: 536 KB
Volume: 22
Category: Article
ISSN: 0009-3084
DOI: 10.1016/0009-3084(78)90026-9

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✦ Synopsis

We report the synthesis of natural ceramide tdhexoside, viz. gal (a-1 ~ 4) gal (#-1 --, 4) gluc (#-1 ~ 1) ceramide (XIII). It involves the Koenigs-Knorr reaction of the bromide II with the aglucon XIX, and of the chloride VII with the D-enantiomer of the ceramide ester XlI. A positional isomer of XIII was obtained as a by-product. A novel technique in the Koenings-Knorr reaction is described.

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