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Total Synthesis of Bafilomycin V 1 : A Methanolysis Product of the Macrolide Bafilomycin C 2

โœ Scribed by Marshall, James A.; Adams, Nicholas D.


Book ID
118745859
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
162 KB
Volume
67
Category
Article
ISSN
0022-3263

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An unprecedented ring expansion in the M
โœ Stephen Hanessian; Qingchang Meng; Eric Olivier ๐Ÿ“‚ Article ๐Ÿ“… 1994 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 284 KB

&&g& When treated with a reagent prepared from equimolar quantities of methyllithium and copper iodide, 7,21-d&O-TMS baf%mycin A2 3 undergoes ring expansion to give the 1 I-membered lactone homolog 5 in nearly quantitative yield. Acid hydrolysis gives iso-bafilomycin Al. Ring contraction to the orig