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Total Synthesis of Antigen Bacillus anthracis Tetrasaccharide — Creation of an Anthrax Vaccine Candidate.

✍ Scribed by Daniel B. Werz; Peter H. Seeberger

Publisher
John Wiley and Sons
Year
2006
Weight
8 KB
Volume
37
Category
Article
ISSN
0931-7597

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Studies towards a Conjugate Vaccine for
Studies towards a Conjugate Vaccine for Anthrax: Synthesis of the Tetrasaccharide Side Chain of the Bacillus anthracis Exosporium
✍ Roberto Adamo; Rina Saksena; Pavol Kováč 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 German ⚖ 186 KB

## Abstract The first synthesis of __β__‐L‐glycoside 17 of the tetrasaccharide __β__‐Ant‐(1 → 3)‐__α__‐L‐Rha__p‐__(1 → 3)‐__α__‐L‐Rha__p‐__(1 → 2)‐L‐Rha__p__ is described (__Schemes 1–3__). Its spacer can be functionalized to make it amenable to conjugation to proteins by different conjugation meth