An efficient total synthesis of the cytotoxic spiroketal natural products aculeatin A and B is described. The synthesis of the 1,3,5-triol moiety with appropriate configuration was accomplished from the commercially available l-malic acid. The key steps in this synthesis are the Barbier allylation,
โฆ LIBER โฆ
Total synthesis of aculeatins A and B from (S)-malic acid
โ Scribed by Ahmed Kamal; Papagari Venkat Reddy; Singanaboina Prabhakar; Moku Balakrishna
- Book ID
- 108284536
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 326 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0957-4166
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