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Total synthesis of AAL-toxin TA1

✍ Scribed by Hideaki Oikawa; Daisuke Yamawaki; Takashi Kagawa; Akitami Ichihara

Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
244 KB
Volume
40
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

Two alternative synthetic routes of the left-half segment 5 have been developed. Efficient condensation between the left and right segments followed by Pd-catalyzed deoxygenation and further elaboration achieved the first total synthesis of AAL-toxin TAI. This allowed us to synthesize various AAL-toxin analogs which would be useful for investigating SAR studies of AAL-toxins.

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