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Total Synthesis of a Thymidine 2-Deoxypolyoxin C Analogue

✍ Scribed by Dehoux, Cécile; Fontaine, Evelyne; Escudier, Jean-Marc; Baltas, Michel; Gorrichon, Liliane


Book ID
126053939
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
119 KB
Volume
63
Category
Article
ISSN
0022-3263

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Synthesis of [2-14C]thymidine: A potenti
✍ T. Vander Borght; Dr. S. Pauwels; L. Lambotte; C. De Saeger; C. Beckers 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 French ⚖ 201 KB

## Abstract We report a three‐step synthesis of thymidine, starting from trace amounts of urea, that allows rapid introduction of radioactivity in C2‐position of the pyrimidine ring. Thymine was produced within 5 min with a 60% yield by cyclocondensation of urea and diethyl β‐methylmalate in fuming