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Total Synthesis of 2′-O-Methylmyxalamide D (I) and (6E)-2′-O-Methylmyxalamide D (II).

✍ Scribed by Robert S. Coleman; Xiaoling Lu; Isabelle Modolo


Book ID
102007295
Publisher
John Wiley and Sons
Year
2007
Weight
21 KB
Volume
38
Category
Article
ISSN
0931-7597

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## Abstract Total synthesis of the natural d-ribo-phytosphingosine I and its 2-epimer III in the protected form was achieved through a common strategy. The aza-Claisen rearrangement of allylic thiocyanate (Z)-V incorporated the new stereogenic centre with nitrogen and the subsequent Wittig olefinat