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Total synthesis of 1.alpha.-fluoro-25-hydroxycholecalciferol and -ergocalciferol

✍ Scribed by Shiuey, Shian Jan; Kulesha, Irina; Baggiolini, Enrico G.; Uskokovic, Milan R.


Book ID
125911379
Publisher
American Chemical Society
Year
1990
Tongue
English
Weight
720 KB
Volume
55
Category
Article
ISSN
0022-3263

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Diastereoselective synthesis, binding af
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A series of analogs of 1,25-dihydroxycholecalciferol and 25hydroxycholecalciferol were obtained with an additional hydroxyl in the aliphatic side chain at carbon atom C-24. These analogs were synthesized by direct and diastereoselective ␣-hydroxylation of enolates derived from respective vitamin D e