Total synthesis of 16-membered tetraene macrolide hygrolidin

✍ Scribed by Kazuishi Makino; Noriyuki Nakajima; Shun-ichi Hashimoto; Osamu Yonemitsu

• Publisher: Elsevier Science
• Year: 1996
• Tongue: French
• Weight: 273 KB
• Volume: 37
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(96)02133-8

✦ Synopsis

The first total synthesis of 16-membered tetraene macrolide antibiotic hygrolidin, a potent and relatively specific inhibitor of the vacuolar ATPases, has been achieved, incorporating macrolactonization by the modified Yamaguchi method and fragment assembly aldol reaction to establish the (717-(718 bond as key steps.