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Total Synthesis and Detection of the Bilirubin Oxidation Product ( Z )-2-(3-Ethenyl-4-methyl-5-oxo-1,5-dihydro-2 H -pyrrol-2-ylidene)ethanamide ( Z -BOX A)

✍ Scribed by Klopfleisch, Maurice; Seidel, Raphael A.; Görls, Helmar; Richter, Hannes; Beckert, Rainer; Imhof, Wolfgang; Reiher, Markus; Pohnert, Georg; Westerhausen, Matthias


Book ID
120998943
Publisher
American Chemical Society
Year
2013
Tongue
English
Weight
348 KB
Volume
15
Category
Article
ISSN
1523-7060

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## Abstract magnified image One‐pot reaction of 3‐aryl‐5‐methyl‐1,3,4‐oxadiazolin‐2‐ones **1a‐g** with ethanolamine yielded the 4‐(2‐hydroxyethyl)‐2‐aryl‐5‐methyl‐2,4‐dihydro‐3__H__‐1,2,4‐triazolin‐3‐ones **2a‐g** which were converted to the azido compounds **6a‐g**. These azides on 1,3‐dipolar cy