Total synthesis and cytotoxicity of bisebromoamide and its analogues

✍ Scribed by Wenhua Li; Shouyun Yu; Mingzhi Jin; Hongguang Xia; Dawei Ma

• Book ID: 104098617
• Publisher: Elsevier Science
• Year: 2011
• Tongue: French
• Weight: 585 KB
• Volume: 52
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2010.11.058

✦ Synopsis

A highly convergent route for assembling bisebromoamide, its stereoisomers and a simplified analogue has been accomplished, which features connecting its left part and right part via thiazoline ring formation at the final stage. Preliminary biological studies revealed that compounds with both proposed and revised structures, and a simplified analogue have similar potency against the proliferation of HeLa S 3 cell, indicating that the stereochemistry of methylthiazoline part, and methyl group at the 4-methylproline residue in bisebromoamide, have limited influence on its cytotoxicity.