Total synthesis and anti-leishmanial activity of R-(−)-argentilactone

✍ Scribed by Muhammad Saeed; Thomas Ilg; Miriam Schick; Muhammad Abbas; Wolfgang Voelter

• Book ID: 104231608
• Publisher: Elsevier Science
• Year: 2001
• Tongue: French
• Weight: 78 KB
• Volume: 42
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)01559-3

✦ Synopsis

Starting from the commercially available D-glucal (2), the naturally occurring a,b-unsaturated d-lactone argentilactone (1a) has been synthesized. The important step is the configuration inversion at C-6 by the Mitsunobu reaction following the sugar-non-sugar-sugar strategy. The synthetic argentilactone has been tested against Leishmania mexicana for bioactivity.