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Total Syntheses of Squamocin A and Squamocin D, Bi-tetrahydrofuran Acetogenins from Annonaceae

โœ Scribed by Ulrich Emde; Ulrich Koert

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
530 KB
Volume
2000
Category
Article
ISSN
1434-193X

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โœฆ Synopsis

The total syntheses of the Annonaceous acetogenins squamocin A and squamocin D have been achieved. The synthesis follows a modular strategy, wherein a left-side chain, the central bis-THF core and the right-side chain are assembled together. Key reactions are additions of organomagnesium

๐Ÿ“œ SIMILAR VOLUMES

Total syntheses of squamocin A and squam
Total syntheses of squamocin A and squamocin D
โœ Ulrich Emde; Ulrich Koert ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 197 KB

The total syntheses of two acetogenins, squamocin A and squamocin D, have been achieved. The adjacent bis-THF subunit was constructed by a multiple Williamson reaction. The left and the right side chain were added by addition of organomagnesium compounds to aldehyde functions. The conversion of a ca