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Total Syntheses of Epothilones B and D

โœ Scribed by Jung, Jae-Chul; Kache, Rajashaker; Vines, Kimberly K.; Zheng, Yan-Song; Bijoy, Panicker; Valluri, Muralikrishna; Avery, Mitchell A.


Book ID
121363808
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
344 KB
Volume
69
Category
Article
ISSN
0022-3263

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Total syntheses of epothilones B and D:
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Following exploratory studies which culminated in syntheses of the alcohol 16, a total synthesis of epothilones B and D is reported in which the trisubstituted 12,13-double-bond is introduced stereoselectively using the tin(IV) bromide-promoted reaction between the allylstannane 22 and the aldehyde

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Total Syntheses of Epothilones A and B. -Distinct ring-forming strategies for the convergent stereocontrolled synthesis of the microtubule-stabilizing title macrolides (I) are developed.