Following exploratory studies which culminated in syntheses of the alcohol 16, a total synthesis of epothilones B and D is reported in which the trisubstituted 12,13-double-bond is introduced stereoselectively using the tin(IV) bromide-promoted reaction between the allylstannane 22 and the aldehyde
โฆ LIBER โฆ
Total Syntheses of Epothilones B and D
โ Scribed by Jung, Jae-Chul; Kache, Rajashaker; Vines, Kimberly K.; Zheng, Yan-Song; Bijoy, Panicker; Valluri, Muralikrishna; Avery, Mitchell A.
- Book ID
- 121363808
- Publisher
- American Chemical Society
- Year
- 2004
- Tongue
- English
- Weight
- 344 KB
- Volume
- 69
- Category
- Article
- ISSN
- 0022-3263
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