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Total lymphoid irradiation therapy in refractory rheumatoid arthritis

✍ Scribed by Ernest Brahn; Simon M. Helfgott; James A. Belli; Ronald J. Anderson; Ellis L. Reinherz; Stuart F. Schlossman; K. Frank Austen; David E. Trentham

Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
666 KB
Volume
27
Category
Article
ISSN
0004-3591

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Because toxicity with the use of 3,000 centiGray (cGy ) of total lymphoid irradiation (TLI) was observed in an earlier study, 2,000-cGy treatments were delivered in a 2-portal format to 7 patients and in a modified 3portal fashion to 6 patients, as part of a randomized, investigator-blinded trial of

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Total lymphoid irradiation (TLI) was administered to 11 patients who had intractable rheumatoid arthritis that was unresponsive to conventional medical therapy, including aspirin, multiple nonsteroidal antiinflammatory drugs, gold salts, and D-penicillamine. Total lymphoid irradiation was given as a