✦ LIBER ✦

Total HCV core antigen assay: A new marker of hepatitis C viremia for monitoring the progress of therapy

✍ Scribed by Alessandro R. Zanetti; Luisa Romanò; Maurizia Brunetto; Massimo Colombo; Giorgio Bellati; Charles Tackney

Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 192 KB
Volume: 70
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.10355

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✦ Synopsis

Abstract

The ability of the total hepatitis C virus (HCV) core antigen assay was evaluated for monitoring the therapeutic responses of HCV‐infected patients treated with interferon. The ability to detect and quantitate an independent structural protein component of HCV, in the presence of circulating antibodies, makes this assay a valuable new tool in diagnosis and treatment monitoring. Measurement of total core antigen showed a strong dynamic correlation with HCV RNA data and may serve as an alternative direct marker of viral infection. In addition, with the advent of additional treatment protocols, a rapid, reliable assay for changes in HCV load may permit more frequent patient assessment and tailoring of the therapeutic regimen. J. Med. Virol. 70: 27–30, 2003. © 2003 Wiley‐Liss, Inc.

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