We have examined the reaction of cyclopropylcarbene-chromium complexes with alkenes. The reaction leads to the formation of cyclopropylcyclopropane derivatives in good yield, accompanied by minor amounts of ring-opened products. Conjugated dienes and a&unsaturated esters and amides appear to be sui
Total diastereoselective synthesis of chromium cyclopropylcarbene complexes
✍ Scribed by José Barluenga; Pablo L Bernad Jr.; JoséM Concellón
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 185 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0040-4039
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Reaction of alkynes having bulky substituents with pentacarbonyl[cyclopropyl(methoxy)methylene]chromium(0) (1) provided cyclopentadienone derivatives. Cyclopentadienones were easily hydrogenated to the corresponding cyclopentenones using chromium hexacarbonyl and water, with no problems resutting fr
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Stereoselective Preparation of Vitamin D Precursors Using the Intramolecular Coupling of Alkynes and Cyclopropylcarbene-Chromium Complexes: A Formal Total Synthesis of (±)-Vitamin D 3 . -The intramolecular coupling of the complexes (III) proceeds with high diastereoselectivity. Catalytic hydrogenati