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Total chemical synthesis of human T-cell leukemia virus type 1 protease via native chemical ligation

✍ Scribed by Changqing Li; Xiangqun Li; Wuyuan Lu

Book ID
102761046
Publisher
Wiley (John Wiley & Sons)
Year
2010
Tongue
English
Weight
1002 KB
Volume
94
Category
Article
ISSN
0006-3525

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Total synthesis of [L40I, C90A, C109A]-h
Total synthesis of [L40I, C90A, C109A]-human T-cell leukemia virus type 1 protease
✍ Kenta Teruya; Toru Kawakami; Kenichi Akaji; Saburo Aimoto πŸ“‚ Article πŸ“… 2002 πŸ› Elsevier Science 🌐 French βš– 147 KB

L40I, C90A, C109A]-Human T-cell leukemia virus type 1 protease, which contains 125 amino acid residues, was synthesized by means of the thioester method. The construction of the backbone of this protease, involved the synthesis of three building blocks, using the Boc solid-phase method. To suppress