Total Chemical Synthesis, Folding, and A
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Erik C. B. Johnson; Thomas Durek; Stephen B. H. Kent
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Article
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2006
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John Wiley and Sons
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English
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Chemical ligation of unprotected peptides has enabled the successful synthesis of a large number of diverse proteins. [1] The native chemical ligation (NCL) reaction, [2] which proceeds in water at neutral pH to yield a native amide bond at the ligation site, has proven to be the most effective chem