Total body irradiation (TBI) as primary therapy for advanced lymphosarcoma

✍ Scribed by Ralph E. Johnson

• Publisher: John Wiley and Sons
• Year: 1975
• Tongue: English
• Weight: 382 KB
• Volume: 35
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(197501)35:1<242::aid-cncr2820350129>3.0.co;2-h

✦ Synopsis

The natural history of lymphocytic lymphomas is such that diffuse involvement usually is present at diagnosis. Extensive lymphatic irradiation with tumoricidal doses is seldom an appropriate form of treatment, as most patients require systemic therapy. W e have investigated total body irradiation(TB1) as a n alternative to chemotherapy. A series of 39 consecutive untreated patients with generalized disease is reviewed. Actuarial 5-year survival rates for the welldifferentiated, poorly differentiated nodular, and poorly differentiated diffuse histologic types are loo%, 78%, and 56% respectively. T h e single major complication, acute myelocytic leukemia, has developed in 2 of the 8 patients given extensive nodal irradiation as a supplement to T B I . None o f the 31 patients receiving only T B I as initial therapy has shown evidence of a niyeloproliferative disorder to date.

Cancer 35:242-246, 1975.