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Total assignment of the 1H and 13C NMR data for felodipine and its derivatives

✍ Scribed by Jihyun Jung; Laehee Kim; Chang Sik Lee; Yoon Hwan Cho; Seung-Ho Ahn; Yoongho Lim

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
105 KB
Volume
39
Category
Article
ISSN
0749-1581

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✦ Synopsis

Abstract

The ^1^H and ^13^C NMR data for felodipine and its derivatives were completely assigned. Felodipine has 3‐ethyl and 5‐methyl esters which make the 1,4‐dihydropyridine asymmetric. It is, however, difficult to distinguish 2,6‐dimethyl groups in the NMR spectra. With the help of NOESY and computer‐aided molecular modeling, these groups can be assigned. Whereas the 1,4‐dihydropyridine of felodipine is connected through a methine carbon to a dichlorophenyl ring, the aromatic pyridine of felodipine derivatives is connected through a quaternary carbon. As a result, the three‐dimensional conformations between the pyridine ring and the phenyl ring have important implications. Copyright © 2001 John Wiley & Sons, Ltd.

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