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Topolsomerase II inhibitors selectively induce cytotoxicity in oestrogen-stimulated human breast cancer cells

✍ Scribed by R.J. Epstein; J.V. Watson; P.J. Smith

Book ID
116006705
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
76 KB
Volume
28
Category
Article
ISSN
0022-4731

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πŸ“œ SIMILAR VOLUMES

Oestrogen potentiates topoisomerase-II-m
Oestrogen potentiates topoisomerase-II-mediated cytotoxicity in an activated subpopulation of human breast cancer cells: Implications for cytotoxic drug resistance in solid tumours
✍ R. J. Epstein; P. J. Smith; J. V. Watson; C. Waters; N. M. Bleehen πŸ“‚ Article πŸ“… 1989 πŸ› John Wiley and Sons 🌐 French βš– 811 KB

Primary resistance to chemotherapeutic agents is a major problem in the management of advanced cancer. By using oestrogen to modulate the topoisomerase II content of T-47D human breast cancer cells, we show here that cell subpopulations resistant to the topoisomerase-ll-interactive drug VP 16 (etopo