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Topology of factor VIII bound to phosphatidylserine-containing model membranes

โœ Scribed by Vivek S. Purohit; Karthik Ramani; Ramesh S. Kashi; Manzer J. Durrani; Timothy J. Kreiger; Sathyamangalam V. Balasubramanian


Book ID
116273749
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
357 KB
Volume
1617
Category
Article
ISSN
0005-2736

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Phosphatidylserine containing liposomes
โœ Karthik Ramani; Razvan D. Miclea; Vivek S. Purohit; Donald E. Mager; Robert M. S ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 257 KB

Factor VIII (FVIII) is a multidomain protein that is deficient in hemophilia A, a clinically important bleeding disorder. Replacement therapy using recombinant human FVIII (rFVIII) is the main therapy. However, approximately 15-30% of patients develop inhibitory antibodies that neutralize rFVIII act