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Topoisomerase II may be linked to the reduction of chromosome number in meiosis

โœ Scribed by Leocadia V. Paliulis; R. Bruce Nicklas


Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
132 KB
Volume
25
Category
Article
ISSN
0265-9247

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Amsacrine (4'-(9-acridinylamino)methanesulphonm-anisidide) is an antileukemic drug which inhibits topoisomerase I 1 (topo 11) enzymes. We studied effects of two concentrations of amsacrine on the GM101 15A cell line. This is a Chinese hamster line containing a single human chromosome 4, which can be