๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Topography and biological role of integrins in human skin

โœ Scribed by Marchisio, Pier Carlo; Trusolino, Livio; De Luca, Michele

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
248 KB
Volume
38
Category
Article
ISSN
1059-910X

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โœฆ Synopsis

We report the topography of integrins in the human epidermis and in cultured human keratinocytes. Both in situ and in vitro โค1 integrins are exposed at the cell-cell adhesion interface while โค4 is located on the basal membrane in contact with the basal lamina. Such defined sorting identifies discrete cell membrane domains that may be involved in defining, building up, and maintaining epithelial cell polarity. The distribution of integrins is deeply altered in hyperproliferative states like those occurring in several experimental conditions and in epidermal diseases.

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