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Topiramate reduces abnormally high extracellular levels of glutamate and aspartate in the hippocampus of spontaneously epileptic rats (SER)

✍ Scribed by Tomoyuki Kanda; Masako Kurokawa; Sachiko Tamura; Joji Nakamura; Akio Ishii; Yoshihisa Kuwana; Tadao Serikawa; Junzo Yamada; Kumatoshi Ishihara; Masashi Sasa


Book ID
116019332
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
654 KB
Volume
59
Category
Article
ISSN
0024-3205

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In vivo acidosis reduces extracellular c
✍ M. Puka; A. Lehmann πŸ“‚ Article πŸ“… 1994 πŸ› John Wiley and Sons 🌐 English βš– 498 KB

## Abstract Microdialysis‐perfusion of the urethane‐anesthetized rat hippocampus was performed to assess the effects of acidosis on extracellular amino acids. Perfusion with Krebs‐Ringer bicarbonate buffer at pH 6.9 produced a selective decrease in taurine. A further reduction of pH to 6.4 induced