Topically applied N-acetylcysteine as a protector against UVB-induced systemic immunosuppression
✍ Scribed by Leon T. van den Broeke; Gerard M.J. Beijersbergenvan Henegouwen
- Book ID
- 103994516
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 435 KB
- Volume
- 27
- Category
- Article
- ISSN
- 1011-1344
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✦ Synopsis
The potential protective efficacy of N-acetylcysteine against systemic immunosuppression in mice, as a result of UVB exposure, was investigated. The contact hypersensitivity response to trinitrochlorobenzene applied at a distant, non-irradiated site, was L~sed to assess the systemic immunosuppression. Topical application of N-acetylcysteine (0.4-3.2 p.mol cm-2), 30 min prior to irradiation (15 kJ m-Z), markedly inhibited the UVB-induced immunosuppression. Because N-acetylcysteine does not absorb UVA or UVB radiation, the mechanism of protection must be different from that of sunscreens. The results of this study raay have important practical implications in protecting human beings against the deleterious effects of UVB radiation.