Topical rose Bengal: Pre-clinical evaluation of pharmacokinetics and safety
✍ Scribed by Eric Wachter; Craig Dees; Jay Harkins; Timothy Scott; Mark Petersen; Rusty E. Rush; Amy Cada
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 255 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0196-8092
No coin nor oath required. For personal study only.
✦ Synopsis
Background and objectives:
Rose bengal (rb) is a potent photosensitizer that has largely been overlooked as a potential photodynamic therapy (pdt) agent. in this study, the feasibility of topical delivery of rb to the epidermis has been evaluated.
Study design/materials and methods:
Topical formulations of rb were assessed on murine and rabbit skin for pharmacokinetic properties, cutaneous toxicity, and photosensitization.
Results:
Hydrophilic formulations (<or=1% rb) exhibited rapid, selective, uniform delivery to the epidermis, with no significant acute cutaneous toxicity in normal skin. illumination (532 nm) elicited no acute phototoxicity for light intensities <or=100 mw/cm(2) at a light dose of 100 j/cm(2); use of higher intensities resulted in superficial thermal damage. repeat treatment of rabbit skin (weekly for four weeks) elicited minor phototoxicity only at the highest concentration (1% rb).
Conclusions:
These results indicate that rb is safe for pdt treatment of skin disorders, exhibiting negligible effects in normal skin.