Topical mosquito repellents III: Carboxamide acetals and ketals and related carbonyl addition derivatives

✍ Scribed by P. Tsakotellis; H. L. Johnson; W. A. Skinner; D. Skidmore; H. I. Maibach

• Book ID: 102913618
• Publisher: John Wiley and Sons
• Year: 1971
• Tongue: English
• Weight: 552 KB
• Volume: 60
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600600116

✦ Synopsis

block vagal degranulation, provides a basis for a hypothesis on adrenergic release of 5-HT from the bowel.

CONCLUSION

The experiments were designed to provide additional information on the effects of vagal stimulation on the granulation of the EC system as a link to the release of 5-HT in the bowel. As evidenced by the data, it was confirmed that peripheral electrical stimulation of the cervical vagus produced a reduction of argentafh-positive EC granulation. This effect was not blocked by atropinization of the animal. C.V.S. and infusion of norepinephrine but not epinephrine produced a similar degranulation. This effect was blocked by both chemical and immunological sympathectomy. Finally, catecholamine-fluorescent fibers were found to be present in the trunk of the cervical vagus in the guinea pig. In short, the mutual agreement in the morphological, histochemical, and physiological observations tested provides a basis for the hypothesis of the noradrenergic release of 5-HT from EC of the guinea pig small bowel.

18, 753(1966).