Topical L-Arginine Gel Lowers Resting An
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N. Griffin; D. D. E. Zimmerman; J. W. Briel; H.-J. Gruss; M. Jonas; A. G. Acheso
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Article
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2002
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Springer
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English
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## Purpose: Exogenous nitric oxide donors, such as glyceryl trinitrate, have been used as treatment for anal fissures; however, headaches develop in 60 percent of patients. nitric oxide produced from the cellular metabolism of l-arginine mediates relaxation of the internal anal sphincter. this stud